Heparin

Heparin induced thrombocytopenia

Abstract Background and Objectives Heparin is still a commonly used anticoagulant in prophylaxis and treatment of thromboembolic events. Heparin-induced thrombocytopenia (HIT) is a life-threating adverse drug reaction of heparin. The diagnosis of HIT is made based on two important criteria, firstly clinical evaluation and secondly laboratory testing. In this comprehensive review, the authors w...

Inhibitory effect of heparin on African Horse-Sickness Virus

Heparin and low-molecular-weight heparin.

Heparin is one of the oldest biological medicines, and has an established place in the prevention and treatment of venous thrombosis. Low-molecular-weight heparins (LMWH) have been developed by several manufacturers and have advantages in terms of pharmacokinetics and convenience of administration. They have been shown to be at least as effective and safe as unfractionated heparin and have repl...

Heparin Resistance During and Post-Intravenous Nitroglycerin Infusion

      Nitroglycerin has been reported to reduce activated partial thromboplastin time (aPTT) values in patients treated with concurrent heparin and nitroglycerin. However, studies have yielded conflicting results. To determine whether intravenous nitroglycerin alters the anticoagulant effect of heparin, we prospectively evaluated twenty patients admitted for coronary angioplasty by measurin...

Heparin Action

THE OBJECTIVE of this editorial is to describe recent progress in our understanding of the biochemical mechanism of heparin's anticoagulant action and to consider ways in which this new knowledge may alter our current methods of monitoring heparin therapy. During the coagulation of blood, thrombin is produced from its precursor, prothrombin, by the concerted action of Factor V and activated Fac...